July 28, 2017 — An obscure Alaska sea sponge, unknown to science until about a decade ago, shows promise as a tool to help patients fight pancreatic cancer, a notoriously deadly and hard-to-treat disease, researchers say.
The sponge, first spotted in 2005 on the floor of the eastern Gulf of Alaska off Baranof Island, holds unusual molecules that target and kill pancreatic cancer cells in the laboratory.
The Alaska sponge now shows more promise as pancreatic-cancer fighter than any of the other sea sponges or plants, marine creatures and bacteria that Mark Hamann of the Medical University of South Carolina and Fred Valeriote of the Henry Ford Cancer Institute in Detroit have examined over the past two decades.
“This is certainly, for us, the best and most exciting looking candidate for the control of pancreatic cancer that we’ve come across in that 20-year period,” Hamann said in a teleconference with reporters Wednesday hosted by the National Oceanic and Atmospheric Association, which is collaborating in the research.
Pancreatic cancer is one of the most difficult cancers to control and spreads rapidly to nearby parts of the body, according to the Mayo Clinic in Rochester, Minnesota. The pancreas is a part of the digestive system, secreting hormones that enable the body to process sugars.
The Alaska sponge was discovered by Bob Stone, a NOAA Fisheries biologist conducting an ocean-floor survey of coral habitat that fishery managers were interested in protecting.
It immediately stood out for its green color, contrasting with the browns common to Southeast Alaska sea sponges, said Stone, who was in the submersible vessel doing the survey. It looked like a sponge from the faraway Aleutians, he said.
“The second I saw it, I thought I should collect it,” he said.